| Expression pattern: |
DN |
| Associated gene: |
FRMD6, PCNA |
| Associated microRNA: |
miR-1291 |
| Biological function: |
Circ_TMCO3 inhibits cervical cancer cell viability, proliferation, migration, invasion, glycolysis and tumor growth, and promotes apoptosis. |
| Molecular mechanism: |
Circ_TMCO3 acts as a ceRNA sponge for miR-1291 to upregulate FRMD6 expression, thereby suppressing cervical cancer progression. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); glycolysis (inhibits); apoptosis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; MTT; EdU Staining; Western Blot; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; Microarray |
| Clinical significance: |
Circ_TMCO3 might become a new molecular marker in the progression, treatment and prognosis of cervical cancer; higher circ_TMCO3 expression is positively correlated with overall survival rate. |
| Description: |
Circ_TMCO3 (hsa_circ_0031027), derived from the TMCO3 gene, is downregulated in cervical cancer tissues and cell lines. Its overexpression suppresses cervical cancer progression by sponging miR-1291 and increasing FRMD6 expression, leading to reduced proliferation, migration, invasion, glycolysis and tumor growth, and increased apoptosis. Higher circ_TMCO3 expression is associated with better overall survival and may serve as a molecular marker for treatment and prognosis. |
| Confidence score: |
0.8155 |