circRNA basic information
circBase ID: hsa_circ_0002015
Name: hsa_circ_MMD
Synonym: circMMD
Host Gene: hsa-miR-15b-5p
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: DBTRG-05MG (DBTRG), U251 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FZD6
Associated microRNA: hsa-miR-15b-5p
Biological function: The knockdown of circMMD significantly repressed the proliferation of DBTRG and U251 cells and also enhanced TTF-mediated suppression of cell proliferation, whereas its overexpression exerted opposite effects
Molecular mechanism: circMMD/hsa-miR-15b-5p/FZD6 axis, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

Our study revealed a novel mechanism of TTF that TTF-mediated reduction of circMMD could inhibit Wnt/beta-catenin pathway to suppress GBM proliferation.
Other information
Title:

circMMD reduction following tumor treating fields inhibits glioblastoma progression through FUBP1/FIR/DVL1 and miR-15b-5p/FZD6 signaling.

Journal: J Exp Clin Cancer Res
Published: 2023/3/19
PubMed ID: 36932454