| Expression pattern: |
UP |
| Associated gene: |
FOXC2 |
| Associated microRNA: |
miR‐526b |
| Biological function: |
Promotes osteosarcoma cell migration and invasion/metastasis. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge (decoy) for miR-526b to post-transcriptionally upregulate FOXC2. |
| Biological pathway or process: |
migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; ISH (In Situ Hybridization); Clinical Sample Validation; Transfection; Transwell Assay; Wound Healing Assay; RNA Pull-Down; Luciferase Reporter Assay; Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Up-regulated circPVT1 correlates with advanced clinical stage, distant metastasis and shorter survival in osteosarcoma patients. |
| Description: |
circPVT1 is up-regulated in osteosarcoma and its high expression is associated with metastasis-related clinicopathological features and poor survival. Mechanistically, circPVT1 promotes migration/invasion by sponging miR-526b, thereby increasing FOXC2 protein expression and driving FOXC2-mediated metastasis. |
| Confidence score: |
0.8544 |