circRNA basic information
circBase ID: hsa_circ_0091579
Name: hsa_circ_GPC3
Synonym: -
Host Gene: GPC3
Genomic location(hg19): chrX:132795757-132888203:-
Genomic location(hg38): chrX:133661729-133754176:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissue samples; matched adjacent non-tumor tissues; liver tumors; paired noncancerous liver tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Serves as a potential diagnostic and prognostic biomarker for HCC; high expression is associated with worse overall survival.
Molecular mechanism: Not experimentally defined in this study.
Biological pathway or process:

not specified
Detected method:
Q
H
M
Validation methods:

Microarray; RT-qPCR; ISH (In Situ Hybridization); Clinical Sample Validation; ROC Analysis; Cohort Study; Survival Analysis; Bioinformatics Analysis
Clinical significance:

High expression is associated with poor prognosis and worse OS; may be useful for diagnosis and prognosis of HCC.
Description:

hsa_circ_0091579 is up-regulated in HCC tumor tissues compared with adjacent non-tumor tissues. Its elevated expression shows diagnostic potential and is associated with worse overall survival, supporting its use as a prognostic biomarker in HCC.
Confidence score:

0.5923
Other information
Title:

Circular RNA Hsa_Circ_0091579 Serves as a Diagnostic and Prognostic Marker for Hepatocellular Carcinoma.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Published: 2018
PubMed ID: 30453307
Study type:

combined biological and clinical study
Data availability: -
Code availability: -