| Expression pattern: |
UP |
| Associated gene: |
HMGB1 |
| Associated microRNA: |
miR-1236-3p |
| Biological function: |
promotes gastric cancer cell proliferation, migration, invasion and glycolysis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA sponge mechanism: circ_0032821 sponges miR-1236-3p to elevate HMGB1 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; CCK8; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; Transfection; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circ_0032821 is up-regulated in gastric cancer tissues/cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration/invasion and glycolysis, at least partly by sponging miR-1236-3p to increase HMGB1 expression, and its knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.7581 |