| Expression pattern: |
UP |
| Associated gene: |
PTEN, BCL2L11 |
| Associated microRNA: |
hsa-miR-106a-5p |
| Biological function: |
potential diagnostic biomarker for FSGS; may participate in regulating podocyte apoptosis |
| Molecular mechanism: |
ceRNA mechanism; sponges hsa-miR-106a-5p and regulates PTEN and BCL2L11 expression |
| Biological pathway or process: |
apoptosis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Microarray; Clinical Sample Validation; RNA Pull-Down; Transfection; Western Blot; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
potential diagnosis index for FSGS; AUC of hsa_circ_0001230 was 0.668, and the two-circRNA panel AUC was 0.763 |
| Description: |
hsa_circ_0001230 is up-regulated in plasma from patients with FSGS and shows potential diagnostic value. Mechanistically, it may act as a sponge for hsa-miR-106a-5p and regulate PTEN/BCL2L11-mediated podocyte apoptosis. |
| Confidence score: |
0.8111 |