circRNA basic information
circBase ID: -
Name: hsa_circ_MTHFD2
Synonym: circ-MTHFD2
Host Gene: MTHFD2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

cancer tissues; adjacent tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Circ-MTHFD2 serves as a clinical biomarker associated with diagnosis, pathological staging, recurrence, lymph node metastasis, and prognosis of NSCLC.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis
Clinical significance:

Circ-MTHFD2 has clinical significance in the diagnosis, pathological staging, and prognosis of NSCLC; high expression is associated with poorer prognosis and is an independent risk factor for overall survival.
Description:

This clinical study found that circ-MTHFD2 is up-regulated in NSCLC cancer tissues compared with adjacent tissues. Its expression is associated with diagnostic ROC performance, TNM stage, lymph node metastasis, recurrence, and poor overall survival, suggesting that circ-MTHFD2 may be a clinical biomarker for NSCLC diagnosis, staging, and prognosis.
Confidence score:

0.5918
Other information
Title:

Clinical significance of circ-MTHFD2 in diagnosis, pathological staging and prognosis of NSCLC.

Journal: European review for medical and pharmacological sciences
Published: 2020
PubMed ID: 33015789
Study type:

clinical study
Data availability: -
Code availability: -