| Expression pattern: |
UP |
| Associated gene: |
CHSY1 |
| Associated microRNA: |
miR-487a-3p |
| Biological function: |
Promotes OSCC cell proliferation and migration and inhibits apoptosis; supports tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-487a-3p to regulate CHSY1 (ceRNA-like mechanism). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Colony Formation Assay; EdU Staining; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0005050 expression was associated with Tumor size and TNM stages. |
| Description: |
circ_0005050 is up-regulated in OSCC tissues and cell lines and promotes malignant phenotypes (proliferation and migration) while inhibiting apoptosis. Mechanistically, it sponges miR-487a-3p to increase CHSY1 expression, and its knockdown suppresses tumor growth in xenograft models. |
| Confidence score: |
0.7589 |