| Expression pattern: |
UP |
| Associated gene: |
BACH1 |
| Associated microRNA: |
miR-382-5p |
| Biological function: |
Promotes GBM cell proliferation, migration, invasion, glycolysis and tumor growth, and suppresses apoptosis. |
| Molecular mechanism: |
circ_0005015 acts as a miRNA sponge for miR-382-5p to up-regulate BACH1 expression in GBM. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); glycolysis (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Bioinformatics Analysis; RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0005015 may provide a potential target or marker for GBM diagnosis, treatment, and prognosis. |
| Description: |
circ_0005015 is up-regulated in GBM tissues and cells and functions as an oncogenic circRNA. It promotes GBM proliferation, migration, invasion, glycolysis, and xenograft tumor growth while inhibiting apoptosis through the circ_0005015/miR-382-5p/BACH1 axis. The study suggests circ_0005015 may be a potential therapeutic target or biomarker for GBM. |
| Confidence score: |
0.8443 |