| Expression pattern: |
UP |
| Associated gene: |
Axin2 |
| Associated microRNA: |
miR-195-5p |
| Biological function: |
Promotes colon cancer cell proliferation, migration and invasion; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-195-5p to modulate Axin2 and affect the Wnt/beta-catenin signaling pathway. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; MTT; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circ_0038718 is up-regulated in colon/colorectal cancer and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, migration, invasion and xenograft tumor growth) by sponging miR-195-5p to upregulate Axin2 and activate Wnt/beta-catenin signaling. |
| Confidence score: |
0.8244 |