circRNA basic information
circBase ID: hsa_circ_0001287
Name: hsa_circ_TCAIM
Synonym: circ_0001287
Host Gene: TCAIM
Genomic location(hg19): chr3:44434346-44442826:+
Genomic location(hg38): chr3:44392854-44401334:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; matched normal adjacent tissues / paracancerous tissues
Cell lines:

H1299; SPC-A1; A549; H2170; H157; 16HBE; 293 T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: PTEN
Associated microRNA: miR-21
Biological function: Inhibits proliferation, migration, invasion, and radioresistance; enhances radiosensitivity in NSCLC cells.
Molecular mechanism: Acts as a ceRNA (miRNA sponge) for miR-21, thereby indirectly up-regulating PTEN expression.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); radioresistance (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; BrdU; Transwell Assay; Colony Formation Assay; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Western Blot
Clinical significance:

Low circ_0001287 expression was associated with low differentiation and positive lymph node invasion/metastasis of NSCLC.
Description:

circ_0001287 is down-regulated in NSCLC tissues and cell lines and functions as a tumor suppressor. It sponges miR-21 to relieve repression of PTEN, thereby inhibiting proliferation/migration/invasion and reducing radioresistance (enhancing radiosensitivity) in NSCLC cells.
Confidence score:

0.6825
Other information
Title:

Circular RNA circ_0001287 inhibits the proliferation, metastasis, and radiosensitivity of non-small cell lung cancer cells by sponging microRNA miR-21 and up-regulating phosphatase and tensin homolog expression.

Journal: Bioengineered
Published: 2021
PubMed ID: 33467964
Study type:

combined biological and clinical study
Data availability: The data used to support the findings of this study are available from the corresponding author upon request.
Code availability: -