| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Serum circSATB2 functions as a blood-based biomarker for distinguishing lung cancer patients from healthy subjects, monitoring postoperative reduction, and identifying early-stage lung cancer stages and subtypes. |
| Molecular mechanism: |
Not mechanistically investigated; the study focused on SERS and CHA-based quantitative detection of serum circSATB2. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
Higher serum circSATB2 levels distinguish lung cancer patients from healthy controls, decrease after surgery, correlate with stage I substage and tumor size classification, and show diagnostic ROC performance. |
| Description: |
This study developed a SERS-CHA optical biosensor to quantify serum circSATB2 in human blood for early lung cancer detection. circSATB2 was higher in lung cancer patients than healthy controls, decreased after surgery, and helped distinguish stage IA/IB and IA subtypes, supporting its use as a liquid biopsy biomarker for screening and treatment monitoring. |
| Confidence score: |
0.4187 |