circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: circ_HIPK3 / circHIPK3
Host Gene: HIPK3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

osteosarcoma tissues; paracancerous tissues; plasma
Cell lines:

SaoS2; HOS; KH-OS; MG63; 143B; U2-OS; hFOB1.19; U2OS
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: suppresses OS cell proliferation, migration and invasion
Molecular mechanism: not specified
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Survival Analysis; ROC Analysis
Clinical significance:

circHIPK3 could be used as a biomarker for diagnosis and prognosis prediction of osteosarcoma; lower circHIPK3 expression correlated with shorter overall survival time and poor prognosis
Description:

circHIPK3 is consistently down-regulated in osteosarcoma cell lines, tumor tissues and patient plasma. Functionally, circHIPK3 overexpression suppresses osteosarcoma cell proliferation/colony formation and inhibits migration and invasion, suggesting a tumor-suppressive role. Clinically, lower circHIPK3 is associated with advanced stage/lung metastasis and worse overall survival, and plasma circHIPK3 shows diagnostic potential by ROC analysis.
Confidence score:

0.6568
Other information
Title:

Circular RNA circ_HIPK3 is down-regulated and suppresses cell proliferation, migration and invasion in osteosarcoma.

Journal: Journal of Cancer
Published: 2018
PubMed ID: 29805712
Study type:

combined biological and clinical study
Data availability: -
Code availability: -