| Expression pattern: |
DS |
| Associated gene: |
APOAI |
| Associated microRNA: |
- |
| Biological function: |
Weakly associated with dyslipidemia through a negative correlation with APOAI; not significantly associated with the incidence or severity of CAD in this study. |
| Molecular mechanism: |
No mechanism was experimentally investigated in this study; circHIPK3 was found to be negatively correlated with APOAI. |
| Biological pathway or process: |
lipid metabolism (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation |
| Clinical significance: |
circHIPK3 showed a weak correlation with dyslipidemia/APOAI, but no significant differences in CAD incidence or severity were detected across circHIPK3 percentiles. |
| Description: |
This clinical study measured serum circHIPK3 by RT-qPCR and found altered expression across coronary status groups, with higher expression in atherosclerosis than in normal coronary artery or CAD groups. circHIPK3 was negatively correlated with APOAI but was not significantly associated with CAD incidence or severity, indicating limited clinical relevance in this cohort. |
| Confidence score: |
0.2995 |