circRNA basic information
circBase ID: hsa_circ_0068087
Name: hsa_circ_GNB4
Synonym: circ-GNB4
Host Gene: hsa-miR-23c
 
 
 
Disease basic information
DO ID:
 557
DO name: kidney disease
Disease details: diabetic nephropathy
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human mesangial cell line HRMC (no. BNCC341276), human podocyte cell line (no. BNCC340460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-23c
Biological function: -
Molecular mechanism: circ-GNB4 could target hsa-miR-23c and EGR1 was targeted by hsa-miR-23c
Survival: -
Supported No.:
 2
Description:

Collectively, circ-GNB4 might be a novel mechanism of DN-induced HRMCs injury, and there was a circ-GNB4/miR-23c/EGR1 pathway underlying the proliferation, extracellular matrix accumulation, inflammation and oxidative stress. This study suggested circ-GNB4 as a potential target to interfere the development of DN.
Other information
Title:

Disrupting circ-GNB4 mitigates high glucose-induced human mesangial cells injury by regulating the proliferation, ECM accumulation, inflammation and oxidative stress through circ-GNB4/miR-23c/EGR1 pathway [RETRACTED].

Journal: J Cardiovasc Pharmacol
Published: 2022/2/17
PubMed ID: 35170486