| Expression pattern: |
UP |
| Associated gene: |
SP1 |
| Associated microRNA: |
miR-203 |
| Biological function: |
Circ_0088036 promotes LUAD cell growth, invasion, and EMT, inhibits apoptosis, and supports xenografted tumor growth in vivo. |
| Molecular mechanism: |
Circ_0088036 functions as a competing endogenous RNA that sponges miR-203, thereby regulating the target gene SP1 in LUAD. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); EMT (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; IF (Immunofluorescence); Western Blot; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry); TUNEL; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_0088036 expression is associated with lymph node metastasis, tumor stage, differentiation, shorter overall survival, and poor prognosis in LUAD. |
| Description: |
Circ_0088036 is up-regulated in LUAD tissues and cell lines, and high expression is associated with poor prognosis and adverse clinicopathological features. Functionally, circ_0088036 promotes LUAD cell growth, invasion, EMT, and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts through a circ_0088036/miR-203/SP1 ceRNA axis. |
| Confidence score: |
0.7976 |