| Expression pattern: |
UP |
| Associated gene: |
YAP1, Ago2, c-Myc, Birc5 |
| Associated microRNA: |
miR-375, miR-30a, miR-330 |
| Biological function: |
promotes proliferation, migration, invasion, and tumorigenesis; inhibits apoptosis (anoikis) |
| Molecular mechanism: |
circFAT1 acts as a miRNA sponge for miR-375 to relieve repression of YAP1, increasing YAP1 and downstream targets (c-Myc, Birc5). |
| Biological pathway or process: |
Hippo/YAP (promotes); ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes) |
| Detected method: |
Q
B
H
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Northern Blot; FISH / smFISH; ISH (In Situ Hybridization); Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; IHC (Immunohistochemistry); IF (Immunofluorescence); Western Blot; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
suggest a new therapeutic target for the treatment of osteosarcoma |
| Description: |
circFAT1 is up-regulated in osteosarcoma tissues and cell lines and is mainly localized in the cytoplasm. It promotes osteosarcoma cell proliferation, migration, invasion and tumorigenesis by sponging miR-375, thereby increasing YAP1 expression (with effects on c-Myc and Birc5) and linking to Hippo/YAP signaling. |
| Confidence score: |
0.8781 |