| Expression pattern: |
UP |
| Associated gene: |
ADGRD1-AS1 |
| Associated microRNA: |
hsa-miR-7-5p |
| Biological function: |
Associated with AD progression in moderate dementia and proposed as a potential biomarker for AD clinical diagnosis and pathological changes; no direct functional assays were performed. |
| Molecular mechanism: |
circRNA-miRNA-lncRNA ceRNA pathway involving upregulated hsa_circ_0001170, downregulated hsa-miR-7-5p, and upregulated ADGRD1-AS1 in the moD group versus the NC group. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
S
|
| Validation methods: |
RNase R Treatment; circRNA-seq; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Potential biomarker for AD clinical manifestations, pathological changes, clinical diagnosis, and therapeutic targeting. |
| Description: |
hsa_circ_0001170 was identified as an upregulated circRNA in peripheral blood from AD patients with moderate dementia compared with normal cognition controls. The study proposes a circRNA-miRNA-lncRNA ceRNA pathway involving hsa_circ_0001170, hsa-miR-7-5p, and ADGRD1-AS1, suggesting potential relevance to AD pathogenesis and biomarker development. |
| Confidence score: |
0.4874 |