| Expression pattern: |
UP |
| Associated gene: |
CREB1, AGO2 |
| Associated microRNA: |
miR-182-5 p |
| Biological function: |
promotes proliferation |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-182-5 p to enhance CREB1 expression; associated with AGO2 occupancy in RISC. |
| Biological pathway or process: |
proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Western Blot; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circ-SFMBT2 was associated with higher tumor stages of gastric cancer and showed diagnostic value by ROC curve (AUC 0.7585). |
| Description: |
circ-SFMBT2 is up-regulated in gastric cancer tissues and plasma and promotes gastric cancer cell proliferation. Mechanistically, it mainly localizes in the cytoplasm and functions as a ceRNA by sponging miR-182-5p to enhance CREB1 expression (circ-SFMBT2/miR-182-5p/CREB1 axis), with diagnostic potential supported by ROC analysis. |
| Confidence score: |
0.8686 |