circRNA basic information
circBase ID: hsa_circ_0009158
Name: hsa_circ_ASPH
Synonym: -
Host Gene: ASPH
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC samples; comparable neighboring normal tissues; HCC tumors; surrounding normal tissues
Cell lines:

PLC; Huh7; Hep3B; SMMC-7721; QSG-7701
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: 248 mRNAs, MELK, NCAPG, BUB1B, BIRC5, CDCA8, CENPF, BUB1, CDK1, TTK, TPX2
Associated microRNA: hsa-miR-942
Biological function: Associated with HCC development and spread; high expression is linked to postoperative recurrence, poor differentiation, tumor thrombosis, shorter recurrence-free survival, and poor overall survival, suggesting a tumor-promoting and prognostic biomarker role.
Molecular mechanism: Predicted ceRNA-associated miRNA-mRNA network in which hsa-circ-0009158 is linked to hsa-miR-942 and 248 mRNAs; enrichment analyses implicated mitotic nuclear division, tubulin binding, and cell cycle-related pathways.
Biological pathway or process:

ceRNA regulation (other); cell cycle (promotes); proliferation (promotes); migration (promotes); invasion (promotes); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis
Clinical significance:

High hsa-circ-0009158 expression was associated with tumor thrombosis, decreased differentiation, tumor recurrence, shorter RFS, poor OS, and may serve as a biomarker for unfavorable prognosis and recurrence risk in HCC.
Description:

hsa-circ-0009158 is up-regulated in HCC tissues and HCC cell lines. Its high expression is associated with adverse clinicopathological features, recurrence, shorter RFS, and poor OS, indicating prognostic biomarker potential. Bioinformatic analyses suggest a hsa-circ-0009158-associated hsa-miR-942-mRNA network involving 248 mRNAs and cell cycle-related processes.
Confidence score:

0.5121
Other information
Title:

Expression of circular RNA has-circ-0009158 and identification of associated miRNA-mRNA network in hepatocellular carcinoma.

Journal: American journal of translational research
Published: 2024
PubMed ID: 38463586
Study type:

combined biological and clinical study
Data availability: TCGA; https://cancergenome.nih.gov; Circular RNA Interactome; https://circinteractome.nia.nih.gov; TargetScan; http://www.targetscan.org/vert_80/; String database; https://string-db.org/; Human Protein Atlas; http://www.protein-atlas.org/
Code availability: -