| Expression pattern: |
UP |
| Associated gene: |
E2F3 |
| Associated microRNA: |
miR-34c-5p |
| Biological function: |
Promotes proliferation, migration and invasion of ectopic endometrial stromal cells, reduces apoptosis, and promotes endometriosis progression in vitro and in vivo. |
| Molecular mechanism: |
circ_0001495 acts as a ceRNA or miRNA sponge for miR-34c-5p to regulate E2F3 expression, thereby promoting endometriosis progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis; In Vivo Animal Model; TUNEL |
| Clinical significance: |
circ_0001495 might be a potential therapeutic target for endometriosis. |
| Description: |
circ_0001495 is up-regulated in endometriosis tissues, serum, and ectopic endometrial stromal cells. It promotes EESC proliferation, migration, and invasion while suppressing apoptosis, and it exacerbates endometriosis progression through the miR-34c-5p/E2F3 ceRNA axis. The study suggests circ_0001495 as a potential therapeutic target for endometriosis. |
| Confidence score: |
0.6545 |