circRNA basic information
circBase ID: hsa_circ_0141900
Name: hsa_circ_RAB1A
Synonym: -
Host Gene: RAB1A
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

non-tumor tissues; tumors; portal vein tumor thrombosis (PVTT)
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: RAB1A, MTOR, RHEB, EIF4EBP1, EIF4E, RPS6KB1
Associated microRNA: -
Biological function: Associated with mTOR signaling pathway (via negative correlation with RAB1A); potential suppression of RAB1A linear RNAs in isoform switch manner.
Molecular mechanism: Negative correlation with parental gene RAB1A; potential isoform switch suppression of RAB1A linear RNAs; pathway association inferred by GSEA correlations.
Biological pathway or process:

PI3K/AKT/mTOR (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0141900 is down-regulated in HCC and shows a strong negative correlation with its host gene RAB1A, suggesting a potential isoform-switch relationship. Its correlated gene signature is enriched for mTOR-related signaling, linking this circRNA to PI3K/AKT/mTOR pathway dysregulation in HCC.
Confidence score:

0.1768
Other information
Title:

Multiple Omics Integration Reveals Key Circular RNAs in Hepatocellular Carcinoma.

Journal: Frontiers in oncology
Published: 2021
PubMed ID: 34094907
Study type:

combined biological and clinical study
Data availability: SRP069212; https://www.frontiersin.org/articles/10.3389/fonc.2021.621353/full#supplementary-material
Code availability: -