circRNA basic information
circBase ID: hsa_circ_0016347
Name: hsa_circ_KCNH1
Synonym: -
Host Gene: KCNH1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

osteosarcoma tissues; adjacent non-tumor tissues
Cell lines:

Saos-2; MG-63; hFOB (OB3)
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: caspase-1 / caspase-1 3′-UTR
Associated microRNA: miR-214, miR-214-3p
Biological function: promotes proliferation, invasion and metastasis of osteosarcoma cells
Molecular mechanism: circ-0016347 acts as a miRNA sponge (ceRNA) for miR-214 to relieve repression of caspase-1
Biological pathway or process:

proliferation (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes); inflammation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; IF (Immunofluorescence); In Vivo Animal Model
Clinical significance:

-
Description:

circ-0016347 is up-regulated in osteosarcoma tissues and cell lines and promotes osteosarcoma cell proliferation, invasion and metastasis. Mechanistically, it functions as a ceRNA/miRNA sponge for miR-214, thereby increasing caspase-1 expression and contributing to inflammation-related tumor progression.
Confidence score:

0.6542
Other information
Title:

Circular RNA hsa-circ-0016347 promotes proliferation, invasion and metastasis of osteosarcoma cells.

Journal: Oncotarget
Published: 2017
PubMed ID: 28424426
Study type:

combined biological and clinical study
Data availability: -
Code availability: -