| Expression pattern: |
UP |
| Associated gene: |
LIN28A, cMYC, Ras |
| Associated microRNA: |
miR-556-5p |
| Biological function: |
Promotes osteosarcoma cell proliferation, migration, metastasis, and malignant progression; high expression is associated with advanced stages and poor prognosis. |
| Molecular mechanism: |
circ_0096041 functions as a ceRNA by sponging miR-556-5p, thereby relieving miR-556-5p-mediated inhibition of LIN28A and increasing LIN28A, cMYC, and Ras expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); metastasis (promotes); ceRNA regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Transwell Assay; Western Blot; IF (Immunofluorescence); In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry) |
| Clinical significance: |
High circ_0096041 expression indicates shorter overall survival, poor prognosis, and association with advanced osteosarcoma stages. |
| Description: |
circ_0096041 is up-regulated in osteosarcoma tissues and cells and acts as an oncogenic circRNA. It promotes proliferation, migration, and in vivo metastasis by sponging miR-556-5p and increasing LIN28A/cMYC/Ras signaling, and its high expression is associated with worse prognosis and advanced stage. |
| Confidence score: |
0.7528 |