| Expression pattern: |
UP |
| Associated gene: |
MAPK1 |
| Associated microRNA: |
miR-655-3p |
| Biological function: |
Promotes PTC cell proliferation, migration, invasion and anti-apoptotic activity; circ-LDLRAD3 knockdown inhibits malignant activities of TPC-1 cells and forces apoptosis. |
| Molecular mechanism: |
circ-LDLRAD3 acts as a ceRNA by binding miR-655-3p, thereby relieving miR-655-3p-mediated repression of MAPK1 and enhancing MAPK1 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes); MAPK (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ-LDLRAD3 expression was associated with tumor size, TNM stage, and lymph node metastasis in PTC patients. |
| Description: |
circ-LDLRAD3 is up-regulated in PTC tissues and cell lines and is associated with tumor size, TNM stage, and lymph node metastasis. Functionally, circ-LDLRAD3 promotes PTC cell proliferation, migration, invasion and resistance to apoptosis. Mechanistically, it sponges miR-655-3p to increase MAPK1 expression, forming a circ-LDLRAD3/miR-655-3p/MAPK1 ceRNA axis. |
| Confidence score: |
0.6536 |