circRNA basic information
circBase ID: -
Name: hsa_circ_PLCL2
Synonym: hsa_circRNA_000361
Host Gene: PLCL2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0011719
MONDO name: gastrointestinal stromal tumor
Disease details: gastrointestinal stromal tumors
Disease DO ID:
 9253
Disease MeSH ID:
 D046152
Disease NCIt ID:
 C3868
Disease ICD11 ID:
 -
Disease OMIM ID:
 606764
Species: Human
Species details: Homo sapiens
Tissue specimen:

GIST tissues; adjacent tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: ceRNA mechanism (predicted circRNA-miRNA-mRNA network)
Biological pathway or process:

Wnt/beta-catenin (other); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

High diagnostic efficiency (ROC AUC = 0.9138) and negatively related with mitotic figure.
Description:

hsa_circRNA_000361 is significantly down-regulated in GIST tissues and is part of a predicted ceRNA network. It shows high diagnostic value and is inversely associated with mitotic activity.
Confidence score:

0.5963
Other information
Title:

Identification of CircRNA-miRNA-mRNA Regulatory Network in Gastrointestinal Stromal Tumor.

Journal: Frontiers in genetics
Published: 2020
PubMed ID: 32547593
Study type:

combined biological and clinical study
Data availability: GSE147303
Code availability: -