| Expression pattern: |
UP |
| Associated gene: |
c-Myc, Ago2 |
| Associated microRNA: |
miR-1294 |
| Biological function: |
promotes proliferation, migration and invasion; inhibits apoptosis; increases ATP production/energy production; promotes tumor growth in vivo |
| Molecular mechanism: |
circEYA3 acts as a ceRNA/miRNA sponge for miR-1294, relieving repression of c-Myc; associated with Ago2/RISC; promotes ATP production |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); EMT (promotes); oxidative phosphorylation (other); other pathway/process (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; Western Blot; IHC (Immunohistochemistry); Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Higher circEYA3 expression is associated with advanced lymph node invasion/TNM stage and predicts poorer overall survival in PDAC patients |
| Description: |
circEYA3 (hsa_circ_0007895), derived from EYA3 and mainly localized in the cytoplasm, is up-regulated in PDAC tissues/cells and correlates with advanced stage and poorer survival. It promotes PDAC proliferation, migration/invasion, and tumor growth while inhibiting apoptosis by acting as a miR-1294 sponge to increase c-Myc expression, thereby enhancing ATP/energy production. |
| Confidence score: |
0.8912 |