| Expression pattern: |
UP |
| Associated gene: |
IL-1alpha |
| Associated microRNA: |
hsa-miR-149-5p |
| Biological function: |
Potentially regulates neuroinflammatory processes in mTLE and may provide a therapeutic target for alleviating mTLE by targeting neuroinflammation. |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0005145 binds hsa-miR-149-5p and regulates IL-1alpha expression. |
| Biological pathway or process: |
ceRNA regulation (other); inflammation (promotes); immune regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNA-seq; Bioinformatics Analysis; Transfection; Western Blot |
| Clinical significance: |
Potential therapeutic target for mTLE by targeting neuroinflammation. |
| Description: |
hsa_circ_0005145 was identified from a human mTLE circRNA-related ceRNA network and was implicated as an up-regulated circRNA. The study proposes and experimentally supports a hsa_circ_0005145/hsa-miR-149-5p/IL-1alpha regulatory axis that may promote neuroinflammation in mTLE and serve as a potential therapeutic target. |
| Confidence score: |
0.4474 |