| Expression pattern: |
DN |
| Associated gene: |
AGO2, NEDD4L, PI3KCA, VEGFA |
| Associated microRNA: |
miR-675 |
| Biological function: |
Suppresses breast cancer cell migration and invasion, tumor growth, metastasis, HUVEC migration and tube formation, and angiogenesis. |
| Molecular mechanism: |
circKDM4B acts as a miR-675 sponge, upregulates NEDD4L, promotes PI3KCA ubiquitination, and inhibits PI3K/AKT signaling and VEGFA secretion. |
| Biological pathway or process: |
ceRNA regulation (other); PI3K/AKT (inhibits); ubiquitination (promotes); migration (inhibits); invasion (inhibits); metastasis (inhibits); angiogenesis (inhibits); VEGF/VEGFR (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; RNA-seq; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Tube Formation Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); ELISA; Western Blot; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circKDM4B expression could distinguish breast cancer tumor tissues from non-tumor tissues with AUC 0.9080 and may be a potential therapeutic target for breast cancer progression. |
| Description: |
circKDM4B (hsa_circ_0002926) is down-regulated in breast cancer tissues and functions as a tumor suppressor. It sponges miR-675 to increase NEDD4L, promoting PI3KCA ubiquitination and inhibiting PI3K/AKT signaling, VEGFA secretion, angiogenesis, migration, invasion, tumor growth and metastasis. Its expression shows diagnostic potential for distinguishing tumor from non-tumor tissues and may represent a therapeutic target. |
| Confidence score: |
0.8933 |