circRNA basic information
circBase ID: hsa_circ_0072309
Name: hsa_circ_LIFR
Synonym: hsa_circRNA_103820
Host Gene: LIFR
Genomic location(hg19): chr5:38523520-38530768:-
Genomic location(hg38): chr5:38523418-38530666:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008903
MONDO name: lung cancer
Disease details: lung cancer
Disease DO ID:
 1324
Disease MeSH ID:
 -
Disease NCIt ID:
 C7377
Disease ICD11 ID:
 -
Disease OMIM ID:
 211980
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

A549; H1299; HEK293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: IGF2BP3
Associated microRNA: -
Biological function: hsa_circRNA_103820 suppresses lung cancer cell viability, migration and invasion, promotes apoptosis, and encodes a 188-aa peptide that inhibits malignant progression.
Molecular mechanism: IGF2BP3 interacts with hsa_circRNA_103820 in an m6A-dependent manner and negatively regulates its expression; hsa_circRNA_103820 encodes a 188-aa peptide that inhibits the AKT pathway.
Biological pathway or process:

proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); PI3K/AKT/mTOR (inhibits); m6A modification (other); other pathway/process (other)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; RIP (RNA Immunoprecipitation); MeRIP / MeRIP-seq; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

This study identifies hsa_circRNA_103820 as a suppressive circRNA in lung cancer cell progression. IGF2BP3 binds hsa_circRNA_103820 in an m6A-dependent manner and negatively regulates its expression, while hsa_circRNA_103820 encodes a functional 188-aa peptide that inhibits LC cell viability, migration and invasion and promotes apoptosis through inhibition of the AKT/PI3K/mTOR pathway.
Confidence score:

0.6945
Other information
Title:

IGF2BP3 loss inhibits cell progression by upregulating has_circRNA_103820, and hsa_circRNA_103820-encoded peptide inhibits cell progression by inactivating the AKT pathway in lung cancer.

Journal: Chemical biology & drug design
Published: 2024
PubMed ID: 38378275
Study type:

biological research
Data availability: available on request from the corresponding author; not publicly available due to privacy or ethical restrictions
Code availability: -