| Expression pattern: |
UP |
| Associated gene: |
DLX2 |
| Associated microRNA: |
miR-582-3p |
| Biological function: |
Circ_HIPK3 facilitates HCC progression by promoting proliferation, migration, invasion, metastasis and tumor growth, and by inhibiting apoptosis; circ_HIPK3 knockdown suppresses these malignant phenotypes. |
| Molecular mechanism: |
Circ_HIPK3 acts as a ceRNA by sponging miR-582-3p, thereby regulating and activating DLX2 expression to promote HCC progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Transfection; Colony Formation Assay; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
Circ_HIPK3 was suggested as a new potential biomarker and promising biomarker for HCC treatment. |
| Description: |
In this study, circ_HIPK3 is up-regulated in HCC tissues and HCC cell lines. Functional experiments indicate that circ_HIPK3 promotes HCC cell proliferation, migration, invasion, metastasis and in vivo tumor growth while suppressing apoptosis. Mechanistically, circ_HIPK3 acts as a ceRNA for miR-582-3p to increase DLX2 expression, suggesting potential value as a biomarker or therapeutic target for HCC treatment. |
| Confidence score: |
0.7595 |