| Expression pattern: |
UN |
| Associated gene: |
CYP1A1, XRCC1 |
| Associated microRNA: |
miR-486-3p |
| Biological function: |
circFLNA promotes lung cancer cell viability, migration, invasion and autophagy, counteracts GA-A-induced apoptosis, and reduces GA-A-mediated sensitization of A549/DDP cells to DDP. |
| Molecular mechanism: |
GA-A downregulates circFLNA and regulates the circFLNA/miR-486-3p/CYP1A1/XRCC1 axis, thereby suppressing autophagy and strengthening cisplatin sensitivity in lung cancer cells. |
| Biological pathway or process: |
autophagy (promotes); apoptosis (inhibits); proliferation (promotes); migration (promotes); invasion (promotes); drug resistance (promotes); chemoresistance (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
This study identifies circFLNA as a component of the GA-A-responsive circFLNA/miR-486-3p/CYP1A1/XRCC1 axis in lung cancer. GA-A downregulates circFLNA, suppresses autophagy, promotes apoptosis, and strengthens cisplatin sensitivity, whereas circFLNA overexpression reverses these anti-tumor and chemosensitizing effects. |
| Confidence score: |
0.4236 |