| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-139-3p, hsa-miR-502-5p, hsa-miR-103a-2-5p, hsa-miR-4677-3p, hsa-miR-500b-5p |
| Biological function: |
Potential oncogene in gastric cancer; promising diagnostic and prognostic marker; associated with histological differentiation, TNM stage, nerve/vascular invasion, lymphatic metastasis, and postoperative monitoring. |
| Molecular mechanism: |
Predicted ceRNA regulatory network centered on hsa_circ_0002762, involving binding to five miRNAs and downstream target mRNAs; cytoplasmic localization suggests post-transcriptional regulation. |
| Biological pathway or process: |
ceRNA regulation (other); metastasis (promotes); proliferation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; ROC Analysis; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0002762 showed diagnostic value for gastric cancer with plasma AUC 0.784, improved sensitivity when combined with CEA and CA19-9, and potential prognostic value for postoperative GC monitoring; high expression was associated with lower survival rate. |
| Description: |
hsa_circ_0002762 is up-regulated in gastric cancer tissues, plasma, and selected GC cell lines, and may act as an oncogenic circRNA. Clinically, its plasma level shows diagnostic value, improves sensitivity when combined with CEA and CA19-9, and high expression is associated with poorer survival. Mechanistically, the study suggests a cytoplasmic post-transcriptional ceRNA network involving hsa_circ_0002762 and five predicted/validated miRNAs. |
| Confidence score: |
0.5734 |