| Expression pattern: |
UP |
| Associated gene: |
TPD52, Ago2 |
| Associated microRNA: |
miR-634 |
| Biological function: |
promotes proliferation, colony formation, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo; promotes cell cycle progression |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0084927 sponges miR-634 to upregulate TPD52 |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; CCK8; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High hsa_circ_0084927 expression was associated with International Federation of Gynecology and Obstetrics (FIGO) stage, lymph node metastasis, and depth of cervical invasion; high expression had a shorter 5-year survival rate. |
| Description: |
hsa_circ_0084927 is up-regulated in cervical cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes malignant phenotypes and tumor growth by sponging miR-634, thereby upregulating the target gene TPD52 (circRNA/miRNA/mRNA axis). High hsa_circ_0084927 expression correlates with adverse clinicopathologic features and poorer survival. |
| Confidence score: |
0.8006 |