circRNA basic information
circBase ID: hsa_circ_0106705
Name: hsa_circ_ACACA
Synonym: -
Host Gene: ACACA
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung carcinoma
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; paired nearby healthy tissues
Cell lines:

BEAS-2B; A549; H1975; H1395; H1793; H1299; H1792
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: PTEN, PI3K, PKB
Associated microRNA: miR-1183
Biological function: promotes proliferation, migration and glycolysis; promotes tumor growth
Molecular mechanism: circ-ACACA acts as a miRNA sponge for miR-1183 and regulates the PI3K/PKB signaling pathway
Biological pathway or process:

proliferation (promotes); migration (promotes); glycolysis (promotes); PI3K/AKT (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Transwell Assay; Western Blot; In Vivo Animal Model; Survival Analysis; ROC Analysis; Bioinformatics Analysis
Clinical significance:

the higher level of circ-ACACA led to the lower survival rate; AUC=0.7822 indicating diagnostic value
Description:

circ-ACACA is up-regulated in NSCLC tissues and cell lines and is associated with advanced stage, metastasis, and poorer overall survival. Functionally, circ-ACACA promotes proliferation, migration and glycolysis and tumor growth by sponging miR-1183, leading to activation of the PI3K/PKB (AKT) pathway (with PTEN up and p-PI3K/p-PKB down upon circ-ACACA knockdown).
Confidence score:

0.848
Other information
Title:

Circular RNA circ‑ACACA regulates proliferation, migration and glycolysis in non‑small‑cell lung carcinoma via miR‑1183 and PI3K/PKB pathway.

Journal: International journal of molecular medicine
Published: 2020
PubMed ID: 32236577
Study type:

combined biological and clinical study
Data availability: The datasets used or analysed during the current study are available from the corresponding author on reasonable request.
Code availability: -