circRNA basic information
circBase ID: hsa_circ_0004491
Name: hsa_circ_ORC4
Synonym: circ_0004491
Host Gene: hsa-miR-2278
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human oral keratinocyte cell line (HOK), OSCC cell lines (CAL-27, HSC-6 , SCC-9, OECM1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: GNAS
Associated microRNA: hsa-miR-2278
Biological function: Circ_0004491 overexpression suppressed the proliferation, migration and invasion whereas facilitated the apoptosis of OSCC cells.
Molecular mechanism: circ_0004491/hsa-miR-2278/GNAS axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

Circ_0004491 can repress OSCC progression by regulation of miR-2278/GNAS axis, providing a possible circRNA-targeted therapy for OSCC.
Other information
Title:

Circ_0004491 stimulates guanine nucleotide-binding protein alpha subunit to inhibit the malignant progression of oral squamous cell carcinoma by sponging miR-2278.

Journal: J Dent Sci
Published: 2023/1/17
PubMed ID: 36643221