| Expression pattern: |
UP |
| Associated gene: |
MAP3K2 |
| Associated microRNA: |
miR-1244 |
| Biological function: |
promotes proliferation |
| Molecular mechanism: |
ceRNA sponge of miR-1244 to upregulate MAP3K2 (MAPK-related factors ERK, JNK, p38 affected) |
| Biological pathway or process: |
proliferation (promotes); MAPK (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Western Blot |
| Clinical significance: |
Potential diagnostic and targeted therapy relevance for PCa |
| Description: |
circUBAP2 is up-regulated in prostate cancer tissues and cell lines and is mainly localized in the cytoplasm. It promotes PCa cell proliferation by sponging miR-1244 to increase MAP3K2 (with downstream MAPK factors such as ERK/JNK/p38 affected). |
| Confidence score: |
0.6676 |