| Expression pattern: |
DN |
| Associated gene: |
ARID4B / AT-rich interaction domain 4B |
| Associated microRNA: |
miR-93-3p, miR-39-3p, miR-39a-3p |
| Biological function: |
Circ-SMARCA5 suppresses CRC tumor progression by inhibiting CRC cell proliferation, migration, invasion, colony formation, and xenograft tumor growth. |
| Molecular mechanism: |
Circ-SMARCA5 functions as a ceRNA by sponging miR-39-3p/miR-93-3p and upregulating ARID4B expression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (other); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis |
| Clinical significance: |
High circ-SMARCA5 expression was correlated with favorable overall survival and may serve as a potential biomarker in CRC patients. |
| Description: |
Circ-SMARCA5 is downregulated in colorectal cancer tissues and cell lines, while higher expression is associated with favorable overall survival. Functionally, circ-SMARCA5 acts as a tumor suppressor that inhibits CRC cell proliferation, colony formation, migration, invasion, and xenograft tumor growth. Mechanistically, it functions through a ceRNA-like axis involving miR-39-3p/miR-93-3p and ARID4B upregulation. |
| Confidence score: |
0.7412 |