| Expression pattern: |
UP |
| Associated gene: |
MET |
| Associated microRNA: |
miR449a |
| Biological function: |
promotes migration and invasion; promotes metastasis/progression of HCC |
| Molecular mechanism: |
ceRNA mechanism involving miR449a and MET |
| Biological pathway or process: |
migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Luciferase Reporter Assay; Transfection; Transwell Assay; In Vivo Animal Model; H&E Staining; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Associated with clinical stage and prognosis in HCC; high circPTGR1 indicates worse disease-free survival |
| Description: |
hsa_circ_0003731 (circPTGR1 isoform) is upregulated in metastatic HCC cell/exosome contexts and in patient serum exosomes, and is linked to stage and poor prognosis. Functionally, circPTGR1 promotes HCC migration/invasion and metastasis through a miR449a-dependent increase of MET. |
| Confidence score: |
0.814 |