circRNA basic information
circBase ID: -
Name: hsa_circ_KIAA0907
Synonym: circKIAA0907
Host Gene: KIAA0907
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002009
MONDO name: major depressive disorder
Disease details: Major depressive disorder
Disease DO ID:
 1470
Disease MeSH ID:
 D003865
Disease NCIt ID:
 C35094
Disease ICD11 ID:
 -
Disease OMIM ID:
 608516
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells; blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-182-5p
Biological function: circKIAA0907 was decreased in PBMCs of MDD patients and showed diagnostic ability to differentiate MDD patients from healthy controls in ROC analysis; no functional experiments were reported for circKIAA0907.
Molecular mechanism: Bioinformatics predicted that circKIAA0907 could potentially bind to miR-182-5p, but no experimental mechanism validation was reported for circKIAA0907.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

circKIAA0907 could differentiate MDD patients from healthy controls, with AUC = 0.709.
Description:

circKIAA0907 was included in an initial clinical qRT-PCR screen of candidate circRNAs predicted to bind miR-182-5p. It was down-regulated in PBMCs from MDD patients and showed moderate diagnostic discrimination, but the study did not pursue mechanistic or functional validation for this circRNA.
Confidence score:

0.459
Other information
Title:

CircPTK2 may be associated with depressive-like behaviors by influencing miR-182-5p.

Journal: Behavioural brain research
Published: 2024
PubMed ID: 38266777
Study type:

clinical study
Data availability: Data will be made available on request; Supplementary data associated with this article can be found in the online version at doi:10.1016/j.bbr.2024.114870.
Code availability: -