| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
miR-182-5p |
| Biological function: |
circPTK2 may serve as a peripheral diagnostic biomarker for MDD; circPTK2 overexpression in mouse hippocampus rescued CUMS-induced depressive-like behaviors including immobility time in FST and average speed deficit in OFT. |
| Molecular mechanism: |
circPTK2 acts as an endogenous sponge for miR-182-5p and reduces the elevated miR-182-5p level in the hippocampus of CUMS mice. |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; In Vivo Animal Model; IF (Immunofluorescence); ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circPTK2 in PBMCs might serve as a potential diagnostic marker for MDD. |
| Description: |
circPTK2 is down-regulated in PBMCs from MDD patients and in the hippocampus of CUMS mice. Its overexpression in the hippocampus alleviates depressive-like behavioral deficits, likely by sponging miR-182-5p, and it may have diagnostic and therapeutic relevance in MDD. |
| Confidence score: |
0.7905 |