| Expression pattern: |
UP |
| Associated gene: |
FUS, FGFR1, CBL |
| Associated microRNA: |
- |
| Biological function: |
circFGFR1 promotes PTC cell proliferation and growth and inhibits cell apoptosis. |
| Molecular mechanism: |
FUS promotes circFGFR1 formation; circFGFR1 acts as a decoy for CBL, inhibits CBL-mediated ubiquitination and degradation of FGFR1 protein, and prolongs FGFR1 protein half-life. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ubiquitination (inhibits); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; TUNEL; Western Blot; RIP (RNA Immunoprecipitation); RNA Pull-Down; Co-IP; Bioinformatics Analysis |
| Clinical significance: |
circFGFR1 is highlighted as a potential therapeutic target for PTC. |
| Description: |
hsa_circ_0008016/circFGFR1 is up-regulated in PTC cells and functions as an oncogenic circRNA by promoting proliferation and inhibiting apoptosis. FUS promotes circFGFR1 formation, and circFGFR1 stabilizes FGFR1 protein by interacting with CBL and suppressing CBL-mediated FGFR1 ubiquitination and degradation. The study proposes circFGFR1 as a potential therapeutic target in PTC. |
| Confidence score: |
0.6578 |