circRNA basic information
circBase ID: hsa_circ_0067934
Name: hsa_circ_PRKCI
Synonym: circ-PRKCI
Host Gene: hsa-miR-545-3p
 
 
 
Disease basic information
DO ID:
 4450
DO name: renal cell carcinoma
Disease details: renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human RCC cell lines (786-O, ACHN, Caki-1, 769-P), normal epithelial cell line (HK-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CCND1
Associated microRNA: hsa-miR-545-3p
Biological function: Tumor cell-derived exosomal circ-PRKCI promoted the proliferation, migration, and invasion of RCC cells, while inhibiting their apoptosis.
Molecular mechanism: circ-PRKCI/hsa-miR-545-3p/CCND1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

In conclusion, this study will provide a new understanding about the molecular mechanisms of RCC progression.
Other information
Title:

Tumor Cell-Derived Exosomal circ-PRKCI Promotes Proliferation of Renal Cell Carcinoma via Regulating miR-545-3p/CCND1 Axis.

Journal: Cancers (Basel)
Published: 2023/1/9
PubMed ID: 36612120