circRNA basic information
circBase ID: -
Name: hsa_circ_FADS2
Synonym: -
Host Gene: FADS2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0000918
MONDO name: endometritis
Disease details: endometritis
Disease DO ID:
 1002
Disease MeSH ID:
 D004716
Disease NCIt ID:
 C26764
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma samples; blood
Cell lines:

HEnEpCs
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-643
Biological function: circFADS2 overexpression promotes mature miR-643 production and protects HEnEpCs from LPS-induced apoptosis; circFADS2 is suggested to suppress LPS-induced inflammation in endometritis.
Molecular mechanism: circFADS2 promotes miR-643 maturation rather than acting as a molecular sponge of miR-643, thereby reducing LPS-induced HEnEpC apoptosis.
Biological pathway or process:

apoptosis (inhibits); inflammation (inhibits); other pathway/process (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; Annexin V/PI Flow Cytometry
Clinical significance:

circFADS2 is downregulated in plasma from endometritis patients and may serve as a potential target for the treatment of endometritis.
Description:

circFADS2 is significantly downregulated in plasma from endometritis patients and is positively correlated with mature miR-643. Functional experiments in HEnEpCs indicate that circFADS2 overexpression promotes miR-643 maturation and suppresses LPS-induced apoptosis, suggesting a protective role in endometritis.
Confidence score:

0.4862
Other information
Title:

CircRNA circFADS2 is Downregulated in Endometritis and its Overexpression Promotes miR-643 Maturation in Human Endometrial Epithelial Cells to Suppress Cell Apoptosis.

Journal: Reproductive sciences (Thousand Oaks, Calif.)
Published: 2021
PubMed ID: 34478121
Study type:

combined biological and clinical study
Data availability: The datasets generated and/or analyzed during the current study are not publicly available due research design but are available from the corresponding author on reasonable request.
Code availability: -