| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
miR-567 |
| Biological function: |
circ_0001681 acts as a tumor-suppressive circRNA in LUAD; its overexpression suppresses LUAD cell proliferation, migration, and invasion, while its downregulation is associated with tumor severity, malignancy, lymph node metastasis, and adverse prognosis. |
| Molecular mechanism: |
circ_0001681 negatively regulates miR-567; miR-567 mediates the inhibitory effect of circ_0001681 on LUAD cell proliferation and motility. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; ROC Analysis; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Reduced circ_0001681 discriminates LUAD patients from healthy individuals and benign lung disease patients; circ_0001681 downregulation is associated with advanced TNM stage, lymph node metastasis, and poorer 5-year survival, and circ_0001681 is an independent prognostic indicator of LUAD. |
| Description: |
circ_0001681 is downregulated in LUAD serum, tumor tissues, and LUAD cell lines. Reduced circ_0001681 has diagnostic and prognostic value, while overexpression suppresses LUAD cell proliferation, migration, and invasion through negative modulation of miR-567. |
| Confidence score: |
0.7404 |