circRNA basic information
circBase ID: -
Name: -
Synonym: hsa_circ_001569
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer tissues; matched normal breast tissues; adjacent non-tumor breast tissue
Cell lines:

MCF-7; MDA-MB-468; MDAMB-231; MDA-MB-231; MDA-MB-453; MCF-10A
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: p-PI3K, p-AKT, PI3K, AKT, N-cadherin, vimentin
Associated microRNA: -
Biological function: Promotes breast cancer cell proliferation, migration, invasion, metastasis-related phenotypes and EMT, and inhibits apoptosis; high expression is associated with lymph node metastasis, advanced clinical stage and poor overall survival.
Molecular mechanism: hsa_circ_001569 promotes breast cancer progression by modulating PI3K-AKT pathway activation; knockdown reduces p-PI3K and p-AKT levels and inhibits EMT marker expression.
Biological pathway or process:

PI3K/AKT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); apoptosis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; Cohort Study; Survival Analysis
Clinical significance:

Overexpression is associated with lymph node metastasis, advanced clinical stage and shorter overall survival; hsa_circ_001569 expression is an independent prognostic factor for 5-year overall survival.
Description:

hsa_circ_001569 is up-regulated in breast cancer tissues and cell lines and high expression predicts poor overall survival. Functional knockdown experiments indicate that it promotes proliferation, migration, invasion, metastasis-related behavior and EMT while inhibiting apoptosis. Mechanistically, it contributes to breast cancer progression by activating the PI3K-AKT pathway.
Confidence score:

0.6589
Other information
Title:

Hsa_circ_001569 is an unfavorable prognostic factor and promotes cell proliferation and metastasis by modulating PI3K-AKT pathway in breast cancer.

Journal: Cancer biomarkers : section A of Disease markers
Published: 2019
PubMed ID: 31104012
Study type:

combined biological and clinical study
Data availability: -
Code availability: -