circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: circ_0000284
Host Gene: HIPK3
Genomic location(hg19): chr11:33307958-33309057:+
Genomic location(hg38): chr11:33286412-33287511:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0015486
MONDO name: keratoconus
Disease details: keratoconus
Disease DO ID:
 10126
Disease MeSH ID:
 D007640
Disease NCIt ID:
 C26806
Disease ICD11 ID:
 945228622
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

corneal tissues; peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Best-performing diagnostic candidate among the tested blood circRNAs; significantly lower in early, moderate, and advanced KC patients than controls.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RT-qPCR; RNA-seq; Clinical Sample Validation; ROC Analysis
Clinical significance:

AUC 0.7306; showed the best diagnostic performance among the four significant blood circRNAs and was significantly lower across early, moderate, and advanced KC.
Description:

circ_0000284 was down-regulated in KC cornea and peripheral blood, including in early, moderate, and advanced KC. It had the best diagnostic performance among the four significant blood circRNAs, supporting its potential as a circulating biomarker for KC.
Confidence score:

0.4679
Other information
Title:

Circular RNA expression profile identifies potential circulating biomarkers for keratoconus.

Journal: Experimental eye research
Published: 2024
PubMed ID: 38142763
Study type:

combined biological and clinical study
Data availability: Available from the corresponding author on reasonable request; Data will be made available on request; Supplementary data can be found online at https://doi. org/10.1016/j.exer.2023.109759.
Code availability: -