| Expression pattern: |
DN |
| Associated gene: |
p53, p21 |
| Associated microRNA: |
hsa-miR-515-5p / hsa_miR-1301-3p / hsa-miR-181c-5p / hsa-miR-22-5p / hsa-miR-141-5p |
| Biological function: |
Downregulation of hsa_circ_0007113 promotes cellular senescence; silencing hsa_circ_0007113 increases p53/p21 expression and SA-beta-gal staining, whereas hsa_circ_0007113 is decreased in aged individuals. |
| Molecular mechanism: |
ceRNA mechanism via miRNA binding; hsa_circ_0007113 binds hsa-miR-515-5p to regulate the p53/p21 signaling pathway. |
| Biological pathway or process: |
p53 signaling (promotes); apoptosis (other); cell senescence (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNA-seq; Microarray; RT-qPCR; Transfection; Western Blot; Flow Cytometry（Non-apoptosis/cycle）; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
The expression level of hsa_circ_0007113 was decreased in aged people, suggesting potential value as a biomarker for human aging/senescence. |
| Description: |
hsa_circ_0007113 is downregulated in senescent IMR-90 cells and in older individuals. Functional inhibition of hsa_circ_0007113 promotes senescence, likely through a miR-515-5p/p53-p21-related ceRNA mechanism. |
| Confidence score: |
0.6221 |