circRNA basic information
circBase ID: -
Name: hsa_circ_NUP98
Synonym: circ-NUP98
Host Gene: NUP98
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor samples; paired adjacent samples; LUAD tumor tissues; resected tumor tissues
Cell lines:

BEAS-2B; HCC827; A549
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: CBX1, Ago2, CyclinD1, Bax, MMP9, KI67
Associated microRNA: miR-188-3p
Biological function: promotes LUAD cell proliferation, migration, invasion, cell-cycle progression, oxidative stress, and tumor growth, and inhibits apoptosis
Molecular mechanism: circ-NUP98 acts as a ceRNA/miRNA sponge for miR-188-3p to increase CBX1 expression
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); cell cycle (promotes); ceRNA regulation (other); other pathway/process (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Wound Healing Assay; ELISA; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry)
Clinical significance:

Circ-NUP98 might provide a potential new marker for early diagnosis of LUAD and potentially effective targets for LUAD treatment.
Description:

circ-NUP98 is up-regulated in LUAD tissues and cell lines and functions as an oncogenic circRNA. Silencing circ-NUP98 suppresses proliferation, migration, invasion, cell-cycle progression, oxidative stress, and xenograft tumor growth while promoting apoptosis. Mechanistically, circ-NUP98 sponges miR-188-3p to relieve repression of CBX1, forming a circ-NUP98/miR-188-3p/CBX1 regulatory axis.
Confidence score:

0.8175
Other information
Title:

Circ-NUP98 Promotes Lung Adenocarcinoma Development Through Regulating CBX1 by miR-188-3p.

Journal: Biochemical genetics
Published: 2024
PubMed ID: 38129720
Study type:

combined biological and clinical study
Data availability: The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -