| Expression pattern: |
UP |
| Associated gene: |
HOXA1 |
| Associated microRNA: |
miR-142-3p |
| Biological function: |
Promotes HCC cell proliferation, migration, invasion, metastasis and tumorigenesis; knockdown suppresses malignant phenotypes and tumour growth in vivo. |
| Molecular mechanism: |
CircWHSC1 acts as a miR-142-3p sponge and upregulates HOXA1 expression, thereby promoting HCC progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circWHSC1 expression was associated with worse overall survival; serum exosomal circWHSC1 may be a diagnostic indicator for HCC with AUC 0.8692. |
| Description: |
CircWHSC1 is up-regulated in HCC tissues, cells and patient serum-derived exosomes. It promotes HCC proliferation, migration, invasion, metastasis and xenograft tumor growth by sponging miR-142-3p and increasing HOXA1 expression. High circWHSC1 expression is associated with poor overall survival, and exosomal circWHSC1 shows diagnostic potential for HCC. |
| Confidence score: |
0.8146 |