circRNA basic information
circBase ID: hsa_circ_0000376
Name: -
Synonym: circ_0000376
Host Gene: -
Genomic location(hg19): chr12:11199618-11248400:-
Genomic location(hg38): chr12:11047019-11095801:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC samples; normal mammary gland samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: 149 differentially expressed mRNAs, DGAT2, ACSL1, ADIPOQ, LPL, LEP, PCK1
Associated microRNA: miR-934, miR-7706, miR-4443, miR-4784
Biological function: Potential involvement in a circRNA-miRNA-mRNA ceRNA regulatory network in breast cancer.
Molecular mechanism: Predicted ceRNA mechanism within a circRNA-miRNA-mRNA regulatory network.
Biological pathway or process:

ceRNA regulation (other); PI3K/AKT (other); AMPK (other); other pathway/process (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

circ_0000376 was identified as a differentially expressed circRNA in breast cancer microarray data and was included in a predicted circRNA-miRNA-mRNA ceRNA network. Its disease association in this paper is supported only by high-throughput and bioinformatics analyses, without reported RT-qPCR or functional validation specific to this circRNA.
Confidence score:

0.1768
Other information
Title:

The investigation of circRNA profiling reveals the regulatory role of the hsa_circ_0000375/miR-7706 pathway in breast cancer.

Journal: Molecular biology reports
Published: 2023
PubMed ID: 37904009
Study type:

bioinformatics study
Data availability: GSE101123; TCGA
Code availability: -