| Expression pattern: |
UP |
| Associated gene: |
NAMPT |
| Associated microRNA: |
miR-127-5p |
| Biological function: |
Promotes OA progression by reducing chondrocyte viability and promoting apoptosis, inflammation, and extracellular matrix degradation. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-127-5p to positively regulate NAMPT expression. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); inflammation (promotes); other pathway/process (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
- |
| Description: |
circ_0128846 is upregulated in OA cartilage and promotes OA-related chondrocyte apoptosis, inflammation, and ECM degradation while suppressing viability. Mechanistically, it functions as a miRNA sponge for miR-127-5p to increase NAMPT expression (circ_0128846/miR-127-5p/NAMPT axis). |
| Confidence score: |
0.7551 |