circRNA basic information
circBase ID: hsa_circ_0020123
Name: -
Synonym: Circ_0020123
Host Gene: -
Genomic location(hg19): chr10:119042605-119049859:-
Genomic location(hg38): chr10:117283094-117290348:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue
Cell lines:

16 HBE; A549; H1299; A549/DDP; H1299/DDP
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: HOXB5
Associated microRNA: miR-140-3p
Biological function: Promotes cisplatin (DDP) resistance and promotes tumor growth in NSCLC.
Molecular mechanism: Acts as a ceRNA by sponging miR-140-3p to upregulate HOXB5, thereby enhancing cisplatin resistance.
Biological pathway or process:

chemoresistance (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model
Clinical significance:

circ_0020123 might be used as a molecular target in DDP treatment for NSCLC.
Description:

circ_0020123 is up-regulated in DDP-resistant NSCLC cells and enhances cisplatin resistance. Mechanistically, it sponges miR-140-3p to increase HOXB5 expression, thereby promoting malignant behaviors and tumor growth under cisplatin treatment.
Confidence score:

0.5634
Other information
Title:

Circ_0020123 enhances the cisplatin resistance in non-small cell lung cancer cells partly by sponging miR-140-3p to regulate homeobox B5 (HOXB5).

Journal: Bioengineered
Published: 2022
PubMed ID: 35170372
Study type:

biological research
Data availability: Supplemental data for this article can be accessed here.
Code availability: -